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Glossary of terms

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Term Definition
disorder of sex development

When a less common path of sex development is taken, the condition is often called a “disorder of sex development” or DSD. DSDs happen in animals as well as humans.

disorders of Sex Development

Disorders of Sex Development (DSD) is defined by the 2006 “Consensus Statement on Intersex Disorders” as “congenital conditions in which development of chromosomal, gonadal, or anatomic sex is atypical.” The definitions of such older terms such as “hermaphrodite” and "“intersex” were considered problematic because of a lack of consensus on definitions and because they labeled persons (rather than conditions). Further, they implicitly labeled patients with a gender, and one that was frequently inappropriate because incongruent with the patient's assigned or experienced gender. Synonyms: DSD

elective

An elective medical procedure is one that is not immediately needed, so the patient, rather than the doctor, can choose whether or not and when to have the procedure.

estrogen

Estrogens are hormones (molecules, or chemical messengers) mainly produced in the ovaries, but also produced to a lesser extent in the adrenal glands and testes. They are responsible for certain types of secondary sex characteristic, like breast development. Estrogens are also responsible for female reproductive processes like helping to regulate the menstrual cycle.

gender

While “sex” usually refers to a person’s physical anatomy, the term “gender” usually refers to mental, social, and cultural characteristics, regardless of anatomy, related to being a boy, girl, man, or woman in our society.

gender identity

A person’s innermost sense of himself or herself as boy or man, girl or woman. This is not simply determined by “sex chromosomes,” by surgery, or by how a child is raised. It is also not chosen by an individual.

gender role

A part that a person plays as a boy, girl, man, or woman in our society. So, for example, being a mother is a gender role.

genital folds

No matter how they end up in terms of sex development, all embryos have genital folds early in the womb, prior to sex development. These folds later develop into the labia majora in most girls and the scrotum in most boys. Children with DSDs sometimes have external genital structures that look in-between labia and scrotum.

genital tubercle

Present in all embryos in early development, the genital tubercle is a structure of the external genitalia that develops into the phallus (in other words, the clitoris or penis).

gonad

“Gonads” is a general term for the sex glands. The term “gonad” can refer to an ovary, a testis (testicle), an ovotestis, or a streak gonad. Mature ovaries usually release eggs until menopause, while mature testes usually produce sperm. In addition, the gonads release hormones that affect the development of the reproductive organs at puberty and affect other physical traits that, after puberty, usually make men and women look different, such as pitch of the voice and body shape and size.

gonadal dysgenesis

Atypical formation of the gonads early in gestation. In complete gonadal dysgenesis, the gonads don't function at all, resulting in female genitalia. In partial gonadal dysgenesis, the testes function, but not at the same level as typical testes, resulting in ambiguous genitalia. In mixed gonadal dysgenesis, a streak gonad develops on one side, and a partially developed testis on the other side.

gonadal ridges

Common in all embryos prior to sex development, gonadal ridges consist of tissue that develops into gonads (ovaries, testes, ovotestes, or gonadal streaks).

gonadal streaks

Gonadal streaks are poorly developed gonad tissue present in place of testes or in place of ovaries in some people with DSDs.

gonadectomy

A "gonadectomy" is a surgery that removes the sex glands (ovaries, testes, or ovotestes).

gynecomastia

Gynecomastia refers to the enlargement of a man’s breasts, usually due to a hormone imbalance or to hormone treatments.

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Quality Care Indicators

View a summary of indicators of high-quality interdisciplinary care for children with disorders of sex development (DSD).

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Review Expert Presentations

Pediatric Academic Societies Mini-Course on DSD Disclosure, University of Michigan DSD Research and Quality Improvement Symposium, and more.

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Questions Answered

Find clear answers to common questions about disorders of sex development (DSD) at Accord Alliance's Frequently Asked Questions page.

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Clinical Pearls

At the Accord Alliance blog, specialists on dedicated DSD teams share their experiences with team-building, reimbursement issues, and more.

Click to read the blog.

Meetings Upcoming

Find dates and informational links for conferences on disorders of sex development (DSD), including meetings of clinicians and support groups.

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